Frequently asked questions (FAQs) about Mytesi

How do I know if Mytesi is right for me?

Mytesi is a prescription medicine to treat noninfectious diarrhea. Noninfectious means the diarrhea is not caused by bacteria, a virus, or a parasite. Mytesi has been studied in and FDA approved specifically for adults living with HIV/AIDS who are on antiretroviral therapy (ART). Ask your doctor if Mytesi is a good choice to help relieve your diarrhea. Get the discussion guide here.

Can I take Mytesi with my ART?

Yes, you can take Mytesi with ART. In clinical studies, Mytesi did not show any drug-drug interactions. It will not affect how well your ART works.

Will Mytesi affect my HIV?

No. Mytesi has no effect on viral load or CD4 counts.

Will I get constipated if I take Mytesi?

Mytesi is not likely to cause you to become constipated. Unlike common medicines for diarrhea, Mytesi does not slow down the GI tract. Slowing down the GI tract can cause constipation. Mytesi works by normalizing the amount of water that flows into the GI tract.  Learn more about how Mytesi works.

What are the side effects of Mytesi?

In clinical studies, people taking Mytesi had the same number of side effects or fewer than people taking placebo. The most common side effects were upper respiratory tract infection (5.7%), bronchitis (3.9%), cough (3.5%), flatulence (3.1%), and higher bilirubin (3.1%).

What’s the right way to take Mytesi?

Take one 125-mg delayed-release tablet of Mytesi twice a day. You can take it with or without food. Mytesi tablets should be swallowed whole. Do not crush or chew the tablets.

How can I get Mytesi?

First, ask your doctor if Mytesi is right for you. Mytesi is a prescription medicine covered by most private insurance, Medicaid, and Medicare plans. It is Napo Pharmaceuticals’ goal to get Mytesi into the hands of any person living with HIV who can benefit from the medicine. So they created the Napo PAP and Mytesi copay savings card. Learn about these programs.

How does Mytesi work?

Mytesi is the only diarrhea medicine that works by normalizing water flow in the GI tract. This gives people relief from watery diarrhea. Learn more about how Mytesi works.

How is Mytesi made?

Mytesi is made from a natural substance called crofelemer. Crofelemer comes from the red bark sap of a tree that grows in the Amazon Rainforest in South America. The sap is harvested from the trees in a sustainable way. The crofelemer is made pure in a laboratory before it is made into Mytesi tablets. Learn how Mytesi is made.